データサイエンス特別講義　第3回（2023年度）

11月1日（水）11:00より、「データサイエンス特別講義　第3回」を開催。
（併催：DSC（データ駆動型サイエンス創造センター）トーク会）

====================

日時： 11月1日（水）11:00-12:30
場所： Rethink 物質創成科学大講義室（MS）＋オンライン(webex)
言語： 英語
講師： 古澤 力 先生（理化学研究所、 東京大学 生命機能科学研究センター 大学院 理学系研究科 生物普遍性研究機構 教授）

演題： 微生物進化の予測と制御へ向けて～大規模進化実験による進化的拘束の解析～

概要：
Biological systems change their state in order to adapt and evolve in response to changing environmental conditions. However, despite recognizing the importance of clarifying the adaptive and evolutionary capabilities of organisms, research on the evolvability and plasticity of organisms remains at a qualitative level. To clarify how evolutionary processes are constrained in high-dimensional phenotypic and genotypic space, we conducted laboratory evolution under various
(～100) stressful environments and analyzed phenotypic and genomic sequence changes [1]. These comprehensive analyses revealed that changes in expression are restricted to low-dimensional dynamics, while diverse genomic changes contribute to similar phenotypic changes. Based on these results, we would like to discuss the nature of phenotypic plasticity and constraints in bacterial evolution [2], as well as possible strategies to predict and control evolutionary dynamics.

[1] T. Maeda et al, Nature Comm., 11:5970 (2020)
[2] C. Furusawa and K. Kaneko, Phys. Rev. E, 97(4-1):042410 (2018)